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Based on data from 2 participants, Irritability is generally lowest after a daily total of 250 milligrams of Bupropion Sr intake over the previous 7 days.
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People with higher Bupropion Sr intake usually have lower Irritability
Each column represents the number of days this value occurred.
This chart shows the typical value recorded for Bupropion Sr on each day of the week.
This chart shows the typical value recorded for Bupropion Sr for each month of the year.
Each column represents the number of days this value occurred.
This chart shows the typical value recorded for Irritability on each day of the week.
This chart shows the typical value recorded for Irritability for each month of the year.

Abstract

Aggregated data from 2 study participants suggests with a medium degree of confidence (p=0.026999947298446, 95% CI -0.534 to 0.319) that Bupropion Sr has a weakly negative predictive relationship (R=-0.11) with Irritability. The highest quartile of Irritability measurements were observed following an average 675.28 milligrams Bupropion Sr per day. The lowest quartile of Irritability measurements were observed following an average 613.80434782609 mg Bupropion Sr per day.

Objective

The objective of this study is to determine the nature of the relationship (if any) between Bupropion Sr and Irritability. Additionally, we attempt to determine the Bupropion Sr values most likely to produce optimal Irritability values.

Participant Instructions

Record your Bupropion Sr daily in the reminder inbox or using the interactive web or mobile notifications.
Record your Irritability daily in the reminder inbox or using the interactive web or mobile notifications.

Design

This study is based on data donated by 2 participants. Thus, the study design is equivalent to the aggregation of 2 separate n=1 observational natural experiments.

Data Analysis

Bupropion Sr Pre-Processing
Bupropion Sr measurement values below 0 milligrams were assumed erroneous and removed. No maximum allowed measurement value was defined for Bupropion Sr. It was assumed that any gaps in Bupropion Sr data were unrecorded 0 milligrams measurement values.
Bupropion Sr Analysis Settings

Irritability Pre-Processing
Irritability measurement values below 1 out of 5 were assumed erroneous and removed. Irritability measurement values above 5 out of 5 were assumed erroneous and removed. No missing data filling value was defined for Irritability so any gaps in data were just not analyzed instead of assuming zero values for those times.
Irritability Analysis Settings

Predictive Analytics
It was assumed that 0.25 hours would pass before a change in Bupropion Sr would produce an observable change in Irritability. It was assumed that Bupropion Sr could produce an observable change in Irritability for as much as 7 days after the stimulus event.
Predictive Analysis Settings

Data Sources

Bupropion Sr data was primarily collected using QuantiModo. QuantiModo allows you to easily track mood, symptoms, or any outcome you want to optimize in a fraction of a second. You can also import your data from over 30 other apps and devices. QuantiModo then analyzes your data to identify which hidden factors are most likely to be influencing your mood or symptoms.

Irritability data was primarily collected using QuantiModo. QuantiModo allows you to easily track mood, symptoms, or any outcome you want to optimize in a fraction of a second. You can also import your data from over 30 other apps and devices. QuantiModo then analyzes your data to identify which hidden factors are most likely to be influencing your mood or symptoms.

Limitations

As with any human experiment, it was impossible to control for all potentially confounding variables. Correlation does not necessarily imply causation. We can never know for sure if one factor is definitely the cause of an outcome. However, lack of correlation definitely implies the lack of a causal relationship. Hence, we can with great confidence rule out non-existent relationships. For instance, if we discover no relationship between mood and an antidepressant this information is just as or even more valuable than the discovery that there is a relationship.
We can also take advantage of several characteristics of time series data from many subjects to infer the likelihood of a causal relationship if we do find a correlational relationship. The criteria for causation are a group of minimal conditions necessary to provide adequate evidence of a causal relationship between an incidence and a possible consequence.

The list of the criteria is as follows:
Strength (A.K.A. Effect Size)
A small association does not mean that there is not a causal effect, though the larger the association, the more likely that it is causal. There is a weakly negative relationship between Bupropion Sr intake and Irritability

Consistency (A.K.A. Reproducibility)
Consistent findings observed by different persons in different places with different samples strengthens the likelihood of an effect. Furthermore, in accordance with the law of large numbers (LLN), the predictive power and accuracy of these results will continually grow over time. 105 paired data points were used in this analysis. Assuming that the relationship is merely coincidental, as the participant independently modifies their Bupropion Sr intake values, the observed strength of the relationship will decline until it is below the threshold of significance. To it another way, in the case that we do find a spurious correlation, suggesting that banana intake improves mood for instance, one will likely increase their banana intake. Due to the fact that this correlation is spurious, it is unlikely that you will see a continued and persistent corresponding increase in mood. So over time, the spurious correlation will naturally dissipate.

Specificity
Causation is likely if a very specific population at a specific site and disease with no other likely explanation. The more specific an association between a factor and an effect is, the bigger the probability of a causal relationship.

Temporality
The effect has to occur after the cause (and if there is an expected delay between the cause and expected effect, then the effect must occur after that delay). The confidence in a causal relationship is bolstered by the fact that time-precedence was taken into account in all calculations.

Biological Gradient
Greater exposure should generally lead to greater incidence of the effect. However, in some cases, the mere presence of the factor can trigger the effect. In other cases, an inverse proportion is observed: greater exposure leads to lower incidence.

Plausibility
A plausible bio-chemical mechanism between cause and effect is critical. This is where human brains excel. Based on our responses so far, 1 humans feel that there is a plausible mechanism of action and 0 feel that any relationship observed between Bupropion Sr intake and Irritability is coincidental.

Coherence
Coherence between epidemiological and laboratory findings increases the likelihood of an effect. It will be very enlightening to aggregate this data with the data from other participants with similar genetic, diseasomic, environmentomic, and demographic profiles.

Experiment
All of human life can be considered a natural experiment. Occasionally, it is possible to appeal to experimental evidence.

Analogy
The effect of similar factors may be considered.

Relationship Statistics

Property Value
Cause Variable Name Bupropion Sr intake
Effect Variable Name Irritability
Sinn Predictive Coefficient 0.012699089703296
Confidence Level medium
Confidence Interval 0.42650592148324
Forward Pearson Correlation Coefficient -0.1078
Critical T Value 1.7945
Total Bupropion Sr intake Over Previous 7 days Before ABOVE Average Irritability 675.28 milligrams
Total Bupropion Sr intake Over Previous 7 days Before BELOW Average Irritability 613.80434782609 milligrams
Duration of Action 7 days
Effect Size weakly negative
Number of Paired Measurements 105
Optimal Pearson Product 0.024206616411443
P Value 0.026999947298446
Statistical Significance 0.45385001430259
Strength of Relationship 0.42650592148324
Study Type population
Analysis Performed At 2019-04-06
Number of Participants 2

Bupropion Sr Statistics

Property Value
Variable Name Bupropion Sr
Aggregation Method SUM
Analysis Performed At 2019-04-05
Duration of Action 7 days
Kurtosis 31.492244463218
Mean 148.01715 milligrams
Median 125 milligrams
Minimum Allowed Value 0 milligrams
Number of Correlations 74
Number of Measurements 2644
Onset Delay 30 minutes
Standard Deviation 48.153600162726
Unit Milligrams
Variable ID 1276
Variance 6117.1290246061

Irritability Statistics

Property Value
Variable Name Irritability
Aggregation Method MEAN
Analysis Performed At 2019-03-26
Duration of Action 24 hours
Kurtosis 4.4960400745927
Maximum Allowed Value 5 out of 5
Mean 2.5165796968056 out of 5
Median 2.4672470652897 out of 5
Minimum Allowed Value 1 out of 5
Number of Correlations 462
Number of Measurements 48412
Onset Delay 0 seconds
Standard Deviation 0.51216330843249
Unit 1 to 5 Rating
Variable ID 1358
Variance 0.57553481012702

Tracking Bupropion Sr

Record your Bupropion Sr daily in the reminder inbox or using the interactive web or mobile notifications.

Tracking Irritability

Record your Irritability daily in the reminder inbox or using the interactive web or mobile notifications.
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https://lh6.googleusercontent.com/-BHr4hyUWqZU/AAAAAAAAAAI/AAAAAAAIG28/2Lv0en738II/photo.jpg Principal Investigator - Mike Sinn